田纳西州田纳西大学的研究人员发表的一项新研究显示, 2 型糖尿病患者如果不好好睡一觉, 就需要更多的时间来愈合伤口。
这项发表在8月11日的《睡眠》杂志上的研究发现, 2 型糖尿病和睡眠中断的超重小鼠需要更多的时间来愈合皮肤创伤。这些结果证实睡眠在2型糖尿病的肥胖小鼠创面愈合中起着特别重要的作用。
在实验中, 科学家们使用了2型糖尿病的肥胖小鼠, 并将其与正常体重的健康小鼠进行了比较。两组小鼠在深麻醉的同时, 背部皮肤上有小切口。科学家们分析了在两种情况下伤口愈合了多长时间: 正常的睡眠时间表和反复中断的睡眠。
结果: 有支离破碎睡眠的糖尿病小鼠需要13天左右的时间才能达到50% 的愈合。相比之下, 即使睡眠中断, 正常体重的健康小鼠的伤口也在五天内达到同样的里程碑。
Poor sleep and type 2 diabetes means slower wound healing
Date:
August 20, 2018
Source:
University of Tennessee at Knoxville
Summary:
People with Type 2 diabetes who don't sleep well could need more time to heal their wounds, according to a new study.
FULL STORY
People with Type 2 diabetes who don't sleep well could need more time to heal their wounds, according to a new study published by researchers from the University of Tennessee, Knoxville.
The research, which appeared online in the journal SLEEP on August 11, found that overweight mice with Type 2 diabetes and disrupted sleep needed more time to heal skin wounds than mice that also had disrupted sleep but didn't have Type 2 diabetes. These results confirm that sleep plays an especially important role in wound healing among obese mice with Type 2 diabetes.
For the experiment, scientists used obesemice with features of Type 2 diabetes and compared them to healthy mice of normal weight. While deeply anesthetized, both groups of mice got a small surgical wound on the skin of their backs. The scientists analyzed how long it took the wound to heal under two scenarios: a normal sleep schedule and sleep that was repeatedly interrupted.
The result: the diabetic mice with fragmented sleep needed about 13 days for their wounds to achieve 50 percenthealing. By contrast, even with sleep interruptions, the wounds of normal-weight healthy mice reached the same milestone in about five days.
Ralph Lydic, Robert H. Cole Endowed Professor of Neuroscience, co-authored the paper with a multidisciplinary team of researchers at UT Knoxville and the UT Graduate School of Medicine. UT Medical Center surgery resident John Mark McLain was the lead author of thestudy. He bridged the UT Graduate School of Medicine's Department of Surgery laboratory of Michael D. Karlstad and the UT Graduate School of Medicine's anesthesiology laboratories of Lydic and Helen A. Baghdoyan, another UT psychology professor.Both Baghdoyan and Lydic hold joint appointments in UT's Department ofPsychology and UT Graduate School of Medicine's Department of Anesthesiology,as well as at Oak Ridge National Laboratory. UT alumni Wateen Alami and ChrisCooley and graduate student Zachary Glovak also participated in this research.
One in three adult Americans suffers from prediabetes, according to the Centers for Disease Control and Prevention.Individuals with prediabetes are at higher risk of developing Type 2 diabetesat some point in their lives.
In people with Type 2 diabetes, high glucose levels lead to poor blood circulation and nerve damage, making the bodymore vulnerable to infections, especially after surgery. Sleep disorders canalso weaken the immune system and slow healing.
Treating wounds in diabetic patients is notonly challenging at a clinical level, it can also get expensive. Just in theUnited States, the cost of treating nonhealing wounds is estimated to top $50 billion a year.
"This is a public health issue, and wewant to contribute to a solution," Lydic said.
Sleep disorders and Type 2 diabetes are intimately connected; it has been widely documented that lack of sleep cancreate metabolic changes like those seen in patients with insulin resistance.
Lydic plans to continue research on thistopic.
"Next we want to explore the effectthat specific drugs have on wound healing in these same groups of mice withdisrupted sleep."
Journal Reference:
John Mark McLain, Wateen H Alami, Zachary T Glovak, Chris R Cooley, Susan J Burke, J Jason Collier, Helen A Baghdoyan, Michael D Karlstad, Ralph Lydic. Sleep Fragmentation Delays Wound Healing in a Mouse Model of Type 2 Diabetes. Sleep, 2018; DOI: 10.1093/sleep/zsy156