王建枝，华中科技大学同济医学院教授，博导。教育部长江学者特聘教授，国家杰出青年基金获得者、入选国家万人计划（教学名师）、湖北省领军人才（第一梯队）、全国师德标兵。兼任教育部生物医学与技术学部委员、华中科技大学神经疾病教育部重点实验室主任、教育部神经变性病创新团队和“985”神经疾病创新平台负责人、华中科技大学学术委员会副主任委员、国家重点学科“病理及病理生理学”学科带头人。主要从事脑老化与老年性痴呆的病理生理机制、早期识别和保护策略研究，在tau蛋白磷酸化机制研究方面做了大量工作，研究结果发表SCI论文140余篇，其中包括Nat Med, Neuron, Prog Neurobiol, PNAS，J Neurosci等国际高影响力杂志；发表论文被国际杂志引用4000余次。科研成果于2010年获国家自然科学奖二等奖，还获湖北省自然科学奖一等奖、教育部自然科学奖一等奖2项、中华医学自然科学奖一等奖等。获国家发明专利2项。主持国家自然科学基金重大研究计划重点项目、重大国际合作项目，科技部国际科技合作与交流专项，美国NIH国际合作项目、国际老年痴呆协会重点项目。担任国际杂志JAD, Neurosci Bull, Front Med等副主编，Alz Res Ther, Neurochem Res, Adv Neurosci Res等编委。主编中、英文版国家规划教材《病理生理学》。
部分研究论文（选自140余篇论文）：
1.Liu D, Wei N, Man HY, Lu Y, Zhu LQ, Wang JZ. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death Differ. 2015 Apr;22(4):583-96
2.Jiang X, Chai GS, Wang ZH, Hu Y, Li XG, Ma ZW, Wang Q, Wang JZ, Liu GP. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Neurobiol Aging. 2015 Feb;36(2):867-76.
3.Jiang Q, Wang L, Guan Y, Xu H, Niu Y, Han L, Wei YP, Lin L, Chu J, Wang Q, Yang Y, Pei L, Wang JZ, Tian Q. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Neurobiol Aging. 2014 Jun;35(6):1352-63.
4.Jiang X, Chai GS, Wang ZH, Hu Y, Li XG, Ma ZW, Wang Q, Wang JZ, Liu GP. Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice. Sci Rep. 2015 Mar 30;5:9488. doi: 10.1038/srep09488
5.Zhang Z, Song M , Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L, Sun YE, Yu SP, Levey AI and Ye K. Proteolytic processing of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease. Nat Med. 2014 Nov;20(11):1254-62
6.Luo HB, Xia YY, Shu XJ, Liu ZC, Feng Y, Liu XH, Yu G, Yin G, Xiong YS, Zeng K, Jiang J, Ye K, Wang XC, Wang JZ. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16586-91.
7.Liu GP, Wei W, Zhou X, Shi HR, Liu XH, Chai GS, Yao XQ, Zhang JY, Peng CX, Hu J, Li XC, Wang Q, Wang JZ. Silencing PP2A Inhibitor by Lenti-shRNA Interference Ameliorates Neuropathologies and Memory Deficits in tg2576 Mice. Mol Ther. 2013 Dec;21(12):2247-57
8.Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, Wang JZ, Wang X . Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.Neurobiol Aging. 2013 Jul;34(7):1748-58.
9.Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R, Wang JZ. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013 Mar;34(3):745-56
10.Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ, Wang JZ. Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. Neurobiol Aging. 2013 Jun;34(6):1555-63.
11.Qu M, Jiang J, Liu XP, Tian Q, Chen LM, Yin G, Liu D, Wang JZ, Zhu LQ. Reduction and the intracellular translocation of EphB2 in Tg2576 mice and the effects of β-amyloid. Neuropathol Appl Neurobiol. 2013 Oct;39(6):612-22.
12.Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y. EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 2012 Feb 23;73(4):774-88.
13.Sun XY, Wei YP, Xiong Y, Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R, Wang JZ. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). J Biol Chem. 2012 Mar 30;287(14):11174-82.
14.Li XH, Zhou XW, Wang JZ. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging. 2012 Jul;33(7):1400-10
15.Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC, Mei L. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci. 2011 Jun 8;31(23):8491-501.
16.Zhu LQ, Zheng HY, Peng CX, Liu D, Li HL, Wang Q and Wang JZ. Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2. J Neurosci. 2010, 30:3839-3848.
17.Zhu LQ, Liu D, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, and Wang JZ. GSK-3 inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010, 30:3824-3833.
18.Hong XP, Peng CX, Wei W, Tian Q, Liu YH, Yao XQ, Zhang Y, Cao FY, Wang Q, Wang JZ. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. 2010, 20(12):1339-49.
19.Liu YH, Wei W, Yin J, Liu GP, Wang Q, Cao FY, Wang JZ. Proteasome inhibition increases tau accumulation independent of phosphorylation. Neurobiol Aging. 2009 Dec;30(12):1949-61.
20.Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP, Zhang Y, Wang JZ. Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am J Pathol. 2009,74(4):1481-1491.
21.Wang JZ, Liu F. Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol. 2008, 85(2):148-175.
22.Zhang CE, Tian Q, Wei W, Peng JH, Liu GP, Zhou XW, Wang Q, Wang DW, Wang JZ. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging. 2008 Nov;29(11):1654-65.
23.Liu GP, Zhang Y, Yao XQ, Zhang CE, Fang J, Wang Q, Wang JZ. Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Neurobiol Aging. 2008 Sep;29(9):1348-58.
24.Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, Tian Q, Wang XC, Chen XQ, Yang Y, Zhang JY, Wang Q, Xu H, Liao FF, Wang JZ. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A. 2007, 104(9):3591-3596.
25.Zhu LQ, Wang SH, Yin YY, Liu D, Zheng HY, Shi HR, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ. Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci. 2007, 27:12211–12220.
26.Wang D, Qian L, Xiong H, Liu J, Neckameyer WS, Oldham S, Xia K, Wang J, Bodmer R, Zhang Z.Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A. 2006, 103(36):13520-13525.
27.Zhang YJ, Xu YF, Liu YH, Yin J, Li HL, Wang Q and Wang JZ. Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms. FASEB J. 2006, 20(9):1431-1442.
28.Liu SJ, Zhang JY, Li HJ, Fang ZY, Wang Q, Deng HM, Gong C, Iqbal K, Wang JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem. 2004, 279(48):50078-50088.
29.Hu YY, He SS, Wang XC, Duan QH, Grundke-Iqbal I, Iqbal K, Wang JZ. Level of nonphosphorylated tau in CSF of Alzhemer disease: An Ultrasensitive bienzyme-substrate-recycle ELISA. Am J Pathol. 2002, 160(4): 1269-1278.
30.Wang JZ, Grundke-Iqbal I, Iqbal K. Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer disease. Nat Med. 1996,2(8): 870-876.