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地 址:江苏省南通市启秀路19号 电 话:0086-513-85051800 传 真:0086-513-85511585 邮 箱:

刘恭平教授


发布者:系统管理员  发布时间:2020-03-29  浏览次数:867


刘恭平,男,教授,博士生导师。华中科技大学学术新人奖,教育部“新世纪优秀人才”计划获得者。教育部及湖北省重大神经系统疾病重点实验室、教育部创新团队学术骨干。主要从事脑老化与老年性痴呆的病理生理机制、早期识别和保护策略研究,研究结果(第一作者或通讯作者)发表文章20多篇,其中包括Chem Sci, Mol Ther, Neurobiol Aging等国际较高影响力杂志。科研成果获湖北省自然科学奖一等奖、中华医学自然科学奖二等奖等(参与人员)。主持国家自然科学基金青年、面上项目、国际老年痴呆协会青年研究者资助项目。担任国际杂志JAD编委,应邀为多家SCI杂志审稿。

发表的有关论文(第一作者或通讯作者):

1. Jiang X, Chai GS, Wang ZH, Hu Y, Li XG, Ma ZW, Wang Q, Wang JZ, Liu GP. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Neurobiol Aging. 2014 Oct 16. pii: S0197-4580(14)00675-7.
2. Shang XL, Wang QB, Liu XP, Yao XQ, Cao FY, Wang Q, Zhang JY, Wang JZ, Liu GP. Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats. Neurosci Lett. 2014 Oct 28;584C:230-235.
3. Zhang Y, Ma RH, Li XC, Zhang JY, Shi HR, Wei W, Luo DJ, Wang Q, Wang JZ, Liu P. Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice. Front Aging Neurosci. 2014 Jun 17;6:123.
4. Luo DJ, Feng Q, Wang ZH, Sun DS, Wang Q, Wang JZ, Liu GP. Knockdown of phosphotyrosyl phosphatase activator induces apoptosis via mitochondrial pathway and the attenuation by simultaneous tau hyperphosphorylation. J Neurochem. 2014 Sep;130(6):816-25.
5. Duan DX, Chai GS, Ni ZF, Hu Y, Luo Y, Cheng XS, Chen NN, Wang JZ, Liu GP. Phosphorylation of tau by death-associated protein kinase 1 antagonizes the kinase-induced cell apoptosis. J Alzheimers Dis. 2013;37(4):795-808.
6. Liu GP, Wei W, Zhou X, Shi HR, Liu XH, Chai GS, Yao XQ, Zhang JY, Peng CX, Hu J, Li XC, Wang Q, Wang JZ. Silencing PP2A inhibitor by lenti-shRNA interference ameliorates neuropathologies and memory deficits in tg2576 mice. Mol Ther. 2013 Dec;21(12):2247-57.
7. Luo Y, Nie YJ, Shi HR, Ni ZF, Wang Q, Wang JZ, Liu GP. PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochim Biophys Acta. 2013 May;1833(5):1235-43.
8. Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS, Wang Q, Wang JZ, Liu GP.Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem. 2013 Feb;124(3):388-96.
9. Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP. Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1. FEBS Lett. 2012 Jul 30;586(16):2522-8.
10. Liu XP, Zheng HY, Qu M, Zhang Y, Cao FY, Wang Q, Ke D, Liu GP, Wang JZ. Upregulation of astrocytes protein phosphatase-2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice. Glia. 2012 Sep;60(9):1279-88.
11. Chen NN, Luo DJ, Yao XQ, Yu C, Wang Y, Wang Q, Wang JZ, Liu GP. Pesticides induce spatial memory deficits with synaptic impairments and an imbalanced tau phosphorylation in rats. J Alzheimers Dis. 2012;30(3):585-94.
12. Wei W, Liu YH, Zhang CE, Wang Q, Wei Z, Mousseau DD, Wang JZ, Tian Q, Liu GP. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. J Alzheimers Dis. 2011;27(3):639-50.
13. Yao XQ, Zhang XX, Yin YY, Liu B, Luo DJ, Liu D, Chen NN, Ni ZF, Wang X, Wang Q, Wang JZ, Liu GP. Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. Biochem J. 2011 Jul 15;437(2):335-44.
14. Liu GP, Wei W, Zhou X, Zhang Y, Shi HH, Yin J, Yao XQ, Peng CX, Hu J, Wang Q,Li HL, Wang JZ. I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis. Neurobiol Aging. 2012 Feb;33(2):254-64.
15. Liu GP, Zhang Y, Yao XQ, Zhang CE, Wang Q, Wang JZ. Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Neurobiol Aging. Neurobiol Aging. 2008 Sep;29(9):1348-58
16. Yao Z, Guo Z, Yang C, Tian Q, Gong CX, Liu G, Wang JZ. Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation. Neuroscience. 2010 Jun 30;168(2):405-15.
17. Liu GP, Shi N. The inhibitory effects of deltamethrin on dopamine biosynthesis in rat PC12 cells. Toxicol Lett. 2006;161(3):195-9.
18. Liu GP, Ma Q, Shi N. Tyrosine hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathway. Biomed Environ Sci. 2006; 19:27-34.


主持基金:

2015年国际自然科学基金(面上);

2013年国家自然科学基金(面上);

2012年国际基金项目 美国阿尔茨海默病协会的青年学者研究基金(第一);

2009年国际基金项目 美国阿尔茨海默病协会的研究者启动研究基金(IIRG-09-13343;第三);

2008年国家自然科学基金青年基金(30801212,第一);

2007年中国博士后科学基金 (二等资助,第一);

国家自然科学基金(30700277,第三);

863计划(2006AA02Z4A1,成员)

教育部创新团队(成员)

2010年华中科技大学学术新人奖

2012年教育部新世纪创新人才计划


所获奖励:

2008年 中华医学科技奖贰等奖 排名第四

2008年 湖北省自然科学奖一等奖 排名第三

2006年 湖北省优秀博士论文奖