王小川，华中科技大学同济医学院基础医学院教授，博士生导师。2007年入选教育部新世纪优秀人才支持计划, 神经系统重大疾病教育部重点实验室青年学术带头人，任湖北省微循环学会副理事长，湖北省病理生理学会常务理事、常务副秘书长。自2000年以来，长期坚持致力于老年性痴呆症（AD）基础研究，在AD病因、发病机制、早期诊断、动物模型建立和防治策略等方面开展了系列研究，发现和完善Tau蛋白降解障碍机制，发展了AD神经原纤维退变学说；阐明内源性PP2A抑制剂SET胞浆滞留分子机制，丰富了AD脑内PP2A活性缺失机制；发现PP2A活性缺失可能是AD与肌萎缩侧索硬化症共患的促发因素；复制出一种基于发病学基础非转基因散发性AD动物模型；发现fMRI BOLD信号与AD样神经病理学改变的内在联系；针对相应分子靶标进行了多项AD药物筛选。在国际上有影响力的刊物PNAS, Acta Neuropathol, FASEB J, J Neurosci, JBC, Neurobiology of Aging, Journal of Neurochemistry, Journal of Alzheimer Disease等杂志发表40多篇经过同行评审的文章。主持和承担了包括国家自然科学基金重点项目、面上项目和863计划等多项科研项目。近5年来发表论文15篇，其中以通讯作者发表论文7篇，单篇平均影响因子5.16，以第一作者发表论文3篇，单篇平均影响因子7.05。主编、参编多本中英文病理生理学统编教材，是人民卫生出版社8年制《病理生理学》和5年制《Pathophysiology》规划教材编写秘书和编委。为多家国际期刊审稿。
近期发表有关的主要论著：（通讯作者*）
1.Wang XC, Blanchard J, Tung YC, Grundke-Iqbal I, Iqbal K*. Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration and Cognitive Impairment in Rats. J Alzheimers Dis. 2015 Jan 1;45(2):423-435. doi: 10.3233/JAD-142403.
2.Luo HB, Xia YY, Shu XJ, Liu ZC, Feng Y, Liu XH, Yu G, Yin G, Xiong YS, Zeng K, Jiang J, Ye K, Wang XC*, Wang JZ*. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16586-16591.
3.Xia Y, Liu R, Chen R, Tian Q, Zeng K, Hu J, Liu X, Wang Q, Wang P, Wang XC*, Wang JZ*. Novel Multipotent AChEI-CCB Attenuates Hyperhomocysteinemia-Induced Memory Deficits and Neuropathologies in Rats. J Alzheimers Dis. 2014; 42(3):1029-1039.
4.Wang XC, Blanchard J, Grundke-Iqbal I, Wegiel J, Deng HX, Siddique T, Iqbal K. Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection. Acta Neuropathol. 2014 Feb;127(2):243-256.
5.Liu XH, Wang ZH, Xia YY, Yu G, Zeng K, Luo HB, Hu JC, Gong CX, Wang JZ, Zhou XW, Wang XC*. Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. J Alzheimers Dis. 2014;40(2):419-27
6.Yu G, Yan TH, Feng Y, Liu XH, Xia YY, Luo HB, Wang JZ, Wang XC*. Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiology of Aging. 2013 Jul;34(7):1748-1758
7.Feng Y, Xia Y, Yu G, Shu X, Ge H, Zeng K, Wang J, Wang XC*. Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H2O2. J Neurochem. 2013 Jul; 126(2):234-242.
8.Iqbal K, Bolognin S, Wang XC, Basurto-Islas G, Blanchard J, Tung YC. Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions. J Alzheimers Dis. 2013;37(3):469-74.
9.Sun XY, Wei YP, Xiong Y, Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R, Wang JZ. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). J Biol Chem. 2012 Mar 30; 287(14):11174-82.
10.Feng Y, Wang XC*. Antioxidant therapies for Alzheimer's disease. Oxid Med Cell Longev. 2012; 2012:472932. doi: 10.1155/2012/472932.
11.Bolognin S, Blanchard J, Wang XC, Basurto-Islas G, Tung YC, Kohlbrenner E, Grundke-Iqbal I, Iqbal K. An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide. Acta Neuropathol. 2012; 123(1):133-151.
12.Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang JZ, Wang XC*. Berberine Attenuates Calyculin A-Induced Cytotoxicity and Tau Hyperphosphorylation in HEK293 Cells. J Alzheimers Dis. 2011; 24(3):525-535
13.Iqbal K, Wang XC, Blanchard J, Grundke-Iqbal I. A non-transgenic rat model of sporadic Alzheimer’s disease. In Animal Models for Neurodegenerative Disease, Avila J, Lucas J, Hernandez F, eds. Royal Society of Chemistry. 2011; pp. 274-283.
14.Wang XC, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K. The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. FASEB J. 2010; 24(11):4420-4432.
15.Iqbal K, Wang XC, Blanchard J, Liu F, Gong CX, Grundke-Iqbal I. Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial. Biochem Soc Trans. 2010; 38(4):962-966.
16.Wang ZF, Yin J, Zhang Y, Zhu LQ, Tian Q, Wang XC, Li HL, Wang JZ. Overexpression of tau proteins antagonizes amyloid-beta-potentiated apoptosis through mitochondria-caspase-3 pathway in N2a cells. J Alzheimers Dis. 2010;20(1):145-157